Waching daily Apr 10 2017

Primary adrenal insufficiency, also known as Addison's disease, is a rare endocrine

disorder that happens when the adrenal gland isn't able to produce enough of the hormones

that the body needs, particularly aldosterone and cortisol.

The reason it's called "primary" is that the underlying problem is localized to

the adrenal gland itself, rather than a problem of a hormone that acts on the adrenal gland

or elsewhere in the body.

Primary adrenal insufficiency can develop acutely or chronically, and a really famous

example of someone having this condition is John F. Kennedy, who was diagnosed at age

30.

Now, there are two adrenal glands, one above each kidney, and each one has an inner layer

called the medulla and an outer layer called the cortex which is subdivided into three

more layers, the zona glomerulosa, zona fasciculata, and the zona reticularis.

The outermost layer is the zona glomerulosa, and it's full of cells that make the hormone

aldosterone.

Aldosterone is part of a hormone family or axis which work together and are called the

renin-angiotensin-aldosterone system.

Together these hormones decrease potassium levels, increase sodium levels, and increase

blood volume and blood pressure.

Aldosterone is secreted in response to elevated levels of renin, and it's role is to bind

to receptors on two types of cells along the distal convoluted tubule of the nephron.

First it stimulates the sodium/potassium ion pumps of the principal cells to work even

harder.

These pumps drive potassium from the blood into the cells and from there it flows down

its concentration gradient into the tubule to be excreted as urine.

At the same time, the pumps drive sodium in the opposite direction from the cell into

the blood, which allows more sodium to flow from the tubule into the cell down its concentration

gradient.

Since water often flows with sodium through a process of osmosis, water also moves into

the blood, which increases blood volume and therefore blood pressure.

The other function of aldosterone is to stimulate the proton ATPase pumps in alpha-intercalated

cells which causes more protons to get excreted into the urine.

Meanwhile, ion exchangers on the basal surface of the cell move the negatively charged bicarbonate

into the extracellular space, causing an increase in pH.

The middle layer is the zona fasciculata, and the cells there make the hormone cortisol

as well as other glucocorticoids.

Cortisol is also needed in times of emotional and physical stress like arguing with a friend

or fleeing from a pack of raccoons.

In those situations, the hypothalamus—which is an almond-size structure which sits at

the base of the brain, releases corticotropin-releasing hormone is released from, and received by

the pituitary gland, the pea-sized structure sitting just underneath the hypothalamus.

In response, the pituitary gland sends out adrenocorticotropic hormone, or ACTH, which

travels through the blood to the zona fasciculata of the adrenal glands and signals cells there

to release cortisol.

Cortisol is a lipid-soluble molecule, meaning it can mingle with fats, which allows it to

easily pass through the plasma membrane of cells and bind to the receptors inside.

In fact, almost every body cell has cortisol receptors, so it affects an huge variety of

functions in the body!

One of cortisol's main jobs though is to increase blood glucose levels by promoting

gluconeogenesis in the liver, gluconeogenesis is the formation of glucose from noncarbohydrate

sources, like amino acids or free fatty acids.

Cortisol also gets the muscles to break down proteins into amino acids and gets adipose

tissues to break down fats into free fatty acids, both of which provide the liver with

more raw materials to work with.

So basically, cortisol keeps blood glucose levels high, and this is in contrast top the

hormone insulin, which causes glucose to be taken up by various body tissues, and so essentially

cortisol acts to counteract this effect this in an effort to make sure that the body can

respond appropriately to those raccoons, or other stressors.

Finally, the innermost layer is the zona reticularis, and cells there make a group of sex hormones

called androgens, including one called dehydroepiandrosterone, which is the precursor of testosterone.

So the adrenal glands are involved in testosterone production in both men and women, but the

amount that the adrenals contribute is pretty small, relative to the testes in men, which

accounts for the very different levels of androgens in men versus women.

In men, high levels of androgens are responsible for the development of male reproductive tissues

and secondary sex characteristics like facial hair and a large larynx or Adam's apple.

In women, low levels of testosterone are responsible for a growth spurt in development, underarm

and pubic hair during puberty, and an increased sex drive in adulthood.

The exact mechanism for adrenal androgen production is not well understood, but like cortisol,

it seems to be stimulated by adrenocorticotropic hormone released from the pituitary gland.

So, that all brings us back to primary adrenal insufficiency, which is where the adrenal

cortex gets progressively damaged over time.

In developed countries the most common cause is autoimmune destruction, when the body's

own immune cells mistakenly attack the healthy adrenal cortical tissues, though the precise

reason why this happens isn't clear.

In developing countries the most common cause is tuberculosis; in this case the infection

spreads from the lungs to the adrenal glands, causing inflammation and destruction in the

adrenal cortex.

Another important cause is metastatic carcinoma, which is where cancer spreads to the adrenal

cortex from somewhere else in the body.

Regardless of the cause, it turns out that the adrenal cortex has a high functional reserve,

meaning that a small amount of functional tissue can still do a pretty decent job of

churning out enough of the hormones to meet the body's needs.

As a result of this though, once there are symptoms, it's usually a sign that a majority,

sometimes up to 90%, of the adrenal cortex has been destroyed.

The symptoms of primary adrenal insufficiency correspond to which layers of the adrenal

cortex have been destroyed.

When the zona glomerulosa is destroyed, aldosterone levels fall and that leads to high potassium

levels in the blood, or hyperkalemia, and low sodium levels in the blood, or hyponatremia.

With less sodium around in the blood, water moves out of the blood vessels, which results

in a low blood volume, or hypovolemia.

Finally, fewer protons are lost, meaning more build up in the blood and that results in

an acidosis, and more specifically a metabolic acidosis, since it's caused by the kidneys.

These electrolyte changes and hypovolemia can cause symptoms like cravings for salty

foods with simultaneous nausea and vomiting, fatigue, and dizziness that worsens with standing.

When the zona fasciculata is destroyed, cortisol levels fall and that leads to inadequate glucose

levels during times of stress.

This means that while being chased by a pack of raccoons, instead of feeling ready to sprint

a person might feel weak, tired, and disoriented.

Also, those decreased levels of cortisol causes the pituitary gland to become overactive,

since usually cortisol ihas a negative feedback effect the pituitary gland.

So it ends up producing pro-opiomelanocortin, which is a precursor to adrenocorticotropic

hormone, but it also turns out to be a precursor to melanocyte-stimulating hormone, the hormone

that leads to skin pigment production.

So when your pituitary gland is overactive, it ends up making more melanocyte-stimulating

hormone, resulting in hyperpigmentation, or darkening of the skin, especially in sun-exposed

areas and joints, like the elbows, knees, and knuckles.

In some extreme cases of primary adrenal insufficiency, the zona reticularis can be affected as well,

and androgens levels can fall.

This decrease doesn't affect men much because remember the testes are the major source of

male androgens.

However women can experience a loss of pubic and armpit hair, as well as a decreased sex

drive.

Oftentimes, the slowly progressive chronic symptoms of primary adrenal insufficiency

are missed or ignored until a major stressor, like a serious injury, surgery, or infection,

suddenly causes the symptoms to become really severe.

In other words the body has a sudden increased need for aldosterone and cortisol, and the

failing adrenal cortex simply can't deliver.

This is known as addisonian crisis, or acute primary adrenal insufficiency, and it usually

happens when the majority of the zona glomerulosa and zona fasciculata are destroyed.

It can cause a sudden pain the lower back, abdomen, or legs, with severe vomiting and

diarrhea, followed by dehydration; low blood pressure; and loss of consciousness.

Left untreated, an addisonian crisis can be fatal.

Addisonian crises can also arise from Waterhouse-Friderichsen syndrome, which is when a sudden increase

in blood pressure causes blood vessels in the adrenal cortex to rupture, filling up

the adrenal glands with blood and causing tissue ischemia and adrenal gland failure.

Primary adrenal insufficiency can be diagnosed with an adrenocorticotropic hormone stimulation

test.

During the test, a small amount of synthetic adrenocorticotropic hormone is given, and

the amount of cortisol and aldosterone produced in response is measured, which helps you figure

out how well the adrenal glands are working.

Usually individuals with primary adrenal insufficiency are treated with hormones to make up for the

lack of cortisol, aldosterone, and androgens.

They typically have to be taken for the rest of an individual's life, and stopping the

hormone replacements can lead to Addisonian crisis.

All right, as a quick recap, primary adrenal insufficiency is a failure of the adrenal

cortex - specifically, the zona glomerulosa which causes low aldosterone, as well as the

zona fasciculata which causes low cortisol, and in severe cases, the zona reticularis,

which causes low androgens.

Thanks for watching, you can help support us by donating on patreon, or subscribing

to our channel, or telling your friends about us on social media.

For more infomation >> Primary adrenal insufficiency (Addison's disease) - pathology, symptoms, diagnosis, treatment - Duration: 11:59.

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2017 Smurfs Lost Village McDonalds Happy Meal COMPLETE SET 6 Unboxing Toy Review - Duration: 7:15.

Hi guys, it's Pierce from Pierce'sWorld.

And today we are going to do the happy meal toys from the Smurfs The Lost Village (Movie.)

If you are new to this channel, please hit that subscribe button right there.

Yes, right there.

So, you don't miss any of my upcoming videos.

My favorite Smurf is Clumsy.

Because he caught the wand.

Everyone thought he can't.

He is like…

I got it!

Now, if you want to see my other Smurfs videos, please click the 'i'.

But enough talking about that.

Let's start opening!

Number one is the red house.

I believe it is Papa Smurf in here.

Here's the disc.

And here's papa Smurf on the front.

The disc says to download Mcplay.

The red house is very detailed.

It has a mushroom top.

Oh, hello Catapillar.

I didn't even see you there.

And there is an open window right there.

So, let's just open the house.

And here's what it looks like on the inside of their house.

That's so cool!

You can color it on the inside.

It comes with two Smurfs.

One holding a flower and Papa Smurf.

I'm ready to do my job!

Watch over my Smurfs!

Now, let's put both of them inside.

I'm going to let you see papa Smurf from the window.

I just saw his belly.

It's pretty cool!

I love these toys.

Alrighty, let's move onto number two.

Number two is the yellow house.

And it has Clumsy one of my favorites.

And look at the house.

It looks a little different.

It is a yellow mushroom house. Now, let me just open this.

So, who do we got in here?

Spitfire – he is a dragonfly.

Look!

Clumsy looks like he hit his head or something.

Or he might be just having a headache.

And here's the other piece that comes on the inside.

Hey, where's the TV?

I guess Smurfs don't watch TV.

They just read books.

The lids can go on very tight.

See!

Let me just…

See!

One hand!

Oh, I'm sorry.

I'm so sorry.

All right, moving on to number three.

Number three is the light green house.

It comes with Smurfette and the painter Smurf.

This is Smurfette's house.

And there is Smurfette, and she is waving "Hi".

Here is painter smurf and he looks like he's about to paint Smurfette.

These figures are so cute.

OK, let's move on to number four.

Number four is the orange house.

And it has Hefty and the bunny.

And the bunny's name is Bucky.

Here's the disc with Hefty on it.

Let me just look at his house.

He has some books and some chairs and some work-out things.

To strengthen his muscles more and more every day.

Here's the bunny.

He glows in the dark!

I'm going to turn off all the lights because this bunny glows.

Here's hefty doing the one arm push-up.

And he has a heart tattoo on his arm.

OK, let's move onto number five.

Number five is the purple house.

Come out purple!

And here is the disc.

And this is Smurf Willow.

She is like Papa Smurf.

We have Baker Smurf.

I am ready to bake!

And we have Smurf Willow.

She has a red hat and red shoes like Papa Smurf.

Smurf Willow has a flower staff.

And the Baker has a cupcake in his hand and a spoon.

It looks like he's about to make some more pie.

You can tell it is Baker's house because you can see there's blueberries right there.

That's a hint.

And you can also see the pie…

That's another hint.

So, what do you think can be on the inside?

Blueberries and pie!

OK let's move onto the last one.

Number six is the light red house.

It has Brainy and Snappy -the ladybug.

Here's the desk with brainy Smurf on it.

Let me show you the inside.

There's some books so you can tell it's brainy Smurf's house.

Here is Snappy the ladybug.

This is brainy Smurf and he is reading a book.

So, this is the complete collection of the Smurfs houses from The Lost Village.

And this months shout outs go to...

Bbuddieez by Jupiter creations.

They sent me toys, and they are also doing a giveaway for all my fans.

So, if you want to check out that video, please click the 'i'.

Yes, the 'i'.

And another shout out goes to Toyboxmagic.

Thank you guys for liking our videos, and posting a photo on your Instagram of your

kids liking our videos.

The last shout out goes to 2Quetee, who says, "Pierce, I love the way you present each toy."

Thank you for leaving me such a sweet comments.

Now, guys remember if you want to shout out, subscribe, like, and comment as often as possible

for a chance to be picked.

Now, if you like this video please give me a big, big, big thumbs up.

And don't forget to subscribe to my channel, Pierce'sWorld. Follow me on Facebook and

Instagram and check out my Pinterest page.

OK, I'll see you guys next time.

Bye!

For more infomation >> 2017 Smurfs Lost Village McDonalds Happy Meal COMPLETE SET 6 Unboxing Toy Review - Duration: 7:15.

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15mayıs94 (Bölüm 2) Dibe vurmak - Duration: 4:04.

For more infomation >> 15mayıs94 (Bölüm 2) Dibe vurmak - Duration: 4:04.

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3D Kids videos - Learn colors with colorful birds Eggs Truck Cars - Education for children toddlers - Duration: 2:12.

3D Kids videos - Learn colors with colorful birds Eggs Truck Cars - Education for children toddlers

For more infomation >> 3D Kids videos - Learn colors with colorful birds Eggs Truck Cars - Education for children toddlers - Duration: 2:12.

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Jet Set Radio Future: Cheep Cheap Games Ep 8 - Duration: 5:50.

Welcome back to Cheep Cheap Games, the show where we talk about great games for great prices!

When I was a young lad, I never owned the original Xbox.

Microsoft was new to the console game, so I was a bit hesitant to buy in.

But there was one game that I always wished I could play

and it was actually developed by my lost love, Sega.

And that game was the spectacularly stylish, Jet Set Radio Future!

An inline skating and graffiti hybrid, that is an essential for Xbox owners

and one you can still pick up without spending too much cash.

Let's check it out!

Jet Set Radio Future was released in 2002 as an Xbox exclusive.

This was the second game in the series,

with the original Jet Grind Radio seeing its home on the Sega Dreamcast.

But after Sega bowed out from the console game,

they went 3rd party and brought their IP's to all of their former competitors.

"Future" was a sort of reimagining of the first game, with a similar story, environments and characters,

but there were enough differences and additions to call it a true sequel.

The game follows a gang of in line skaters, called the GG's, as they have turf wars with other rival gangs.

Now, when you think gangs you must be thinking they're some pretty tough customers,

but all the gangs here in Tokyo-To seem to solve their differences by simply having races or trick contests.

It's quite civil really.

The GG's are also caught up in a battle with crooked cops, and a mega corporation

who controls the city and want to destroy freedom of expression.

With a task that big, the gang should have some pretty extraordinary weapons, right?

Actually, they are only armed with cans of spray paint and their sick inline skates!

You have a few characters to choose from at the start of the game but you can unlock

a lot of others who all have different stats as well as their own unique style.

One of the first things you'll notice is that the focus is not really about doing tricks.

In fact each character has a limited amount, especially if you compare it to games like

Aggressive InLine or Tony Hawks Pro Skater.

Your main objectives are typically to tag over rival gangs graffiti with your own,

participate in races or to mimic an opponents trick line.

The controls are really simple with a button to jump, one to trick, and another one to spray your graffiti.

Jumping is especially floaty and it can catch new players by surprise,

but it lets you catch some serious air and cross huge gaps.

When you jump on to a rail you can perform a grind and it will help you get places faster.

And forget about the laws of physics!

Because you can even grind up 90 degree angles.

It's awesome!

Littered through out the stages are cans of spray paint

which are your ammunition for tagging and you can hold up to 30.

If you have more than 10 cans you can do a jet boost to send your character speeding across the streets

Each level will have certain spots you need to tag and you can view them on your map.

Get to that location and spray away to complete a level!

And unlike its's predecessor, here all the levels are interconnected which make it actually

feel like a city, with traffic and people walking around.

Skating through crowds will send people running in every direction, as they shout at the reckless skaters.

Boy, does it remind me of my youth…

There are no longer time limits, which I really like, because now you don't have to rush around

and can explore these large levels at your own pace.

Surprisingly enough, there are even boss battles.

The leader of the cops will often send hordes of minions out to stop you from tagging the town.

Sometimes he'll even personally come to attack you with guns, choppers,

and other types of mechanical weaponry.

All you need to do is spray some paint on the baddies to blind them

and this will somehow make them explode!

Graffiti is a central theme, so what kind of game would this be if it didn't give you cool looking options!

Each level has secret Graffiti souls to collect and this will increase the amount of designs you can tag with.

You can even design your own works of art in the graffiti editor

and then you can spray your work all over Tokyo!

But if you're like me and suck at art, this might not get too much play time.

But for those artists out there it's a nice addition and I'm sure you can make some awesome stuff.

Around the time this game came out a lot of other games were doing

a similar graphical style with cel-shading.

Jet Set Radio Future looks fantastic even 15 years later

and the cel-shading is a perfect fit for the graffiti motif.

I've always really loved this style.

The character design is highly original, and gives the game a futuristic feeling

with the way each character is dressed.

Yup, the gameplay and graphics are down right fun at every level,

but yet they are still eclipsed by the amazing soundtrack.

The music is what ties the whole atmosphere together featuring an eclectic mix of genres.

There's punk, hip hop, J-pop, electronic and funk all thrown into a pot

and cooking up an underground in-line skating stew.

It's so impressive that all this variety can meld together and fit the games tone so well.

Listening to any track in the game will leave it stuck in my head for the next few hours.

What add's to the authenticity of the underground feel, is that you get to know the DJ spinning the tracks.

Professor K is not only the DJ but he also provides you intel on the goings on in Tokyo

via the pirate radio station Jet Set Radio.

Jet Set Radio Future and the original have a small devout following of fans, and it's easy to see how

this game influenced others like Sunset Over Drive, Splatoon, and Hover: Revolt of Gamers.

It's a shame how this never saw another sequel, but it's an inexpensive cult class

you don't want to miss out on!

If you're a fan of outrageous arcade style games that you can pick up and play anytime,

then make room in your collection for Jet Set Radio Future!

Prices currently range from about 15-25 dollars, and it's definitely worth it.

But wait a second, this is Cheep Cheap Games!

We like our games under 10 bucks!

So, if you really wanna save some cash, Jet Set Radio Future came on a split CD with Sega GT racing,

and that edition can be found for well under 10 dollars, and I picked up mine for 3!

Steal of the century.

Thanks for watching everyone, I'll see you next time. And remember

"It's All Fun and Games!"

Thanks for watching everyone!

If you liked that video, why not check out some more episodes of Cheep Cheap Games

by clicking the playlist down below!

If you really like "It's All Fun And Games" then don't forget to subscribe

so you can get updates when a new video drops.

Thanks again!

For more infomation >> Jet Set Radio Future: Cheep Cheap Games Ep 8 - Duration: 5:50.

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New Dinotrux Mega Construx Crater Rumble Set With Spinosaurus, TREX Learn Dinosaur Names Unboxing - Duration: 17:13.

Wow guys welcome to today's episode

New Dinotrux Mega Construx Crater Rumble Set With Spinosaurus, TREX Learn Dinosaur Names Unboxing

destruction tie rocks being built but we

are also going to identify these ten

dinos that we have here we're going to

listen to some sounds they make learn

how to spell their names and have a lot

of fun with them and learn some cool

facts so stay tuned for that after we go

ahead and review the toys okay super

excited today we've got another also

mega construct dinotrux said today this

is the crater rumble with a hundred of

one pieces it looks awesome so you gotta

tie rock you gotta d struck and revit

and let's check out the back okay it

says collect them all I've already done

a review on the dozer one looks like I

got the tie rocks the tun tun one left

and then this is some of the options of

each trigger ok let's open this up and

have some fun ok let's see what was in

the block super excited to hear this

mega construct sensor also

okay so we got bunch of bags you got one

bag two bag three a little revit for bag

five bags six seven eight nine and ten

ten bags here also and then these mega

constructs are a lot easier to put

together than Lego so our smaller

children should have what needs your

time to do it see if it shows you this

doesn't look like it's going to show the

other set usually they'll show the other

okay here's the other sense which

already showed you so it shows all of

them here okay awesome let's put this

together and have some fun okay guys

first we're gonna go ahead and take a

look at tie rocks because he looks

totally awesome so you've seen how he

went together so it's not complicated ah

this is very good for our like younger

kids because it's much bigger pieces

than Lego okay and uh good moving parts

us back we'll move here like that you

could ah the shovel here you could have

put together to pick something up like

for instance let's go ahead and pick up

revit so squeeze around rub its body

here and it might be too heavy the whole

yeah

but I good for imagination play then but

you could still open and close it that's

cool he's got arms that spin around his

mouth opens and closes like quite a bit

so you could have it like picking up or

and eating whore and stuff so that is

really cool and then there he is and

then we also have awesome be strong so

he has a spinning blade on the back here

so if you push it hard it'll spin like a

pretty good amount and this moves back

and forth so he could cut stuff up with

his blade moving arms rolling wheels

because both of them they do have wheels

under their tread so they roll along

really nicely you can see his eyes are

on this side where it tie rocks is on

the front his mouth opens all the way

off also so you could have them eating

or or attacking so you could have them

like attack each other is trying to cut

them grab them with displayed lift them

up and flip them over Wow have a lot of

fun then on top of that it comes with

this cool little oasis here you would

have or so you could have them like eat

the or whatever I mean to have tie rocks

or or you could take the or and put it

on his head like a helmet I'm so

hilarious and then it comes with awesome

little rabbit here it comes with this

little oasis which we got here with a

sign of revit making schematic of how

our tie rocks could like attack these

trucks and beat them then we got a nice

little palm tree that goes here so guys

this is a really awesome fun set

and now we're going to have these guys

helped us to identify some awesome

Brosius dinosaurs three

okay our first I know is gonna be a huge

one this is the COS effect bull t-rex

from fat suit poor guy is huge he does

roar his mouth opens all the way up he

could swallow full-size action figures

if you want to see some awesome battles

with him and also uh see him being

unboxed go ahead and check out the

Jurassic world playlist at the end of

this video let's go ahead and place this

guy right back here by the gate also

destructs better watch out and here we

got the next awesome title do you know

what this guy is all right he's a Carnot

or a long solo

as women die no this guy is freaking

because when you move his leg he opens

his mouth all the way up check that out

I mean that is freaky looking and he has

called the diamond I know because he's

got two horns on the front of his head

here so this is a really good nice

classic collectors one it does cost

quite a bit though the only place you

could find this one is on ebay so like I

said this guy's totally awesome if you

want to see a awesome battle with him

and unboxing go to the end of this video

okay then we're going to set this guy

over here by the gates right next to the

bold t-racks and here is our next I know

helping this goofy-looking guy

the baby t-rex and this is the one that

actually gets taken and mobile trailer

in one of the Jurassic Park movies

because it has a broken leg so this one

actually comes with a cast I don't have

the cast but here you can see his leg

like separate there so it looks like

bone their mouth goes open and closed so

this one is cool lookin too we're going

to go ahead and place this one right

back here with the bull t-rex and

pretend that that is in Swami okay and

who is this little guy wha cause it's

kind of cool this is a magic asaurus and

this is why Safari limited i also have

all proven fucker so you can see it

almost looks like a herbivore but then

when you look how sharp it piqued our

this is definitely a carnivore so I

think we're gonna place this one right

here hiding in the weeds sort of like

the Velociraptor would okay and who is

this little guy like armored back he's

got like a club tail he looks really

cool yes you're right this is this is a

u+ f away so that name is kind of hard

to pronounce by Safari limited we cool

Dino this an herbivore or carnivores you

are correct that is an herbivore we're

going to go ahead and place her over

here and then we have another awesome

Dino this lovable guy is

mark correct that is not a lovable

little guy third cloth who's using

giveaway yeah is a velociraptor this was

made by papal I also did a full review

on that and papal does a great job on

dinosaur models pretty similar papo &

schleich a pretty similar in like

quality and build texture and everything

of these dinos so we're going to go

ahead and place the Velociraptor back

here in the weeds too hopefully it won't

eat our herbivores okay our next Dino is

creaking rolled in shit this is a ramp

or incus and flying so the chorus or you

can see this if you are seeing the

drastic world oo app game I got all

reviews on that too i also have a lot of

episodes on my gaming channel WD tech

toys if you want to check that out so

this is a ramp or incus and judging by

those teeth this is definitely a

carnivore so we're going to go ahead and

place this freaky looking guy up in the

tree okay this next guy is freaky

looking he is not a dino he is what's

called a life's a nap you could see like

the big teeth big canine teeth he's got

in the front there similar to a

saber-toothed tiger so this guy was

vicious a vicious predator and I think

we should place this guy may be on the

island over here awesome and then next

who is this guy this guy's got like the

big spins that compound on the side here

trying to make a stop look more

ferocious so what do you think

Dilophosaurus is right and this is a

Jurassic Park Dilophosaurus you can see

because it says JP there and it has a

number so this one I arms and its legs

move and it is really cool looking I

think we'll place this one back here

like right by the waterfall enjoying

swim in the back here and then our last

Dino of the day I get to this is too

hard is another Carnotaurus

cool this one is made by Safari limited

so this is a really cool one and

carnivore or herbivore you're correct

that is a carnivore so we're going to go

ahead and place this guy right back here

by the jurassic world one the big

Jurassic Park carnotaurus okay guys so

this is all all bar dinos let's go ahead

and count how many we had not counting

these trucks or tie rocks so we've got

one two three four five six seven eight

nine and ten also so ten new awesome

dinos for you guys to see if you guys

enjoyed this video make sure you click

like that's the thumbs up button under

the video drop me a comment guys I read

your comments I will get back to you as

soon as possible and if you did like

this mega construct set I'll have a

place under my video where you could buy

it I belong to amazon affiliate program

so I get a small sales commission from

that what it costs through the same so

you are getting an awesome toy and

helping out my channel thanks for

viewing and being oh wow guys that was a

lot of fun and if you enjoyed the video

make sure you click subscribe and thumbs

up button down below the video in

today's secret word is the word

good put that in the comments section

down below the video I'll know you

remember my club look to the video ends

there's an awesome and Kurt lot more fun

with you and I click the boxes below for

a lot more fun videos and if you want to

see even more go ahead and click the

subscribe button

For more infomation >> New Dinotrux Mega Construx Crater Rumble Set With Spinosaurus, TREX Learn Dinosaur Names Unboxing - Duration: 17:13.

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Top 11 Lincoln Quotes - Duration: 4:12.

Now you've said it.

Plenty of people rae on to the emptiness,

but

it takes real guts to see the hopelessness.

You know he isn't to be trusted. Trust? Oh.

I'm sorry, I was under the misapprehension that your chosen profession was politics.

I never trusted the President, never trusted anyone,

but hasn't he surprised you?

As the preacher said,

"I could write shorter sermons, but once I start, I get too lazy to stop."

I don't hold with equality in all things, only with equality before the law. Nothing more.

Slavery is the only insult to natural law, you fatuous nincompoop!

But say all we done is show the world that democracy isn't chaos.

That there is a great, invisible strength in a people's union.

Euclid's first common notion is this,

Things which are equal to the same thing are equal to each other.

That's a rule of mathematical reasoning. It's true because it works.

If in pursuit of your destination, you plunge ahead,

heedless of obstacles and achieve nothing more than to sink in a swamp.

We begin with equality.

That's the origin, isn't it?

That's balance. That's...

That's fairness.

That's justice.

and that government of the people,

by the people,

for the people

shall not perish from the earth.

Negroes have been fighting and dying for freedom

since the first of us was a slave.

I never heard any ask

what freedom would bring.

Freedom is first.

For more infomation >> Top 11 Lincoln Quotes - Duration: 4:12.

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「華語歌曲」Hito中文排行榜3月20日~3月26日 - Duration: 2:53.

For more infomation >> 「華語歌曲」Hito中文排行榜3月20日~3月26日 - Duration: 2:53.

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April the Giraffe: I Didn't Know I Was Pregnant - Duration: 3:19.

Hi everyone. My name is April the

world-famous giraffe

I'm actually the first giraffe to ever give birth.

honest with you I didn't really know

what was pregnant yeah it came to the

surprise to me and my boyfriend's Oliver

and I know there's a lot of controversy

between the two of us because I'm 15 and

well he's five I'm not a cougar I'm a

giraffe where's my moscato thank you you

know draft of the world's tall and hold

why did you pick your bed I was annoyed

this whole thing blew up you know I just

find a movie deal terrific giraffes it's

going to be huge between me and you not

really pregnant I just want attention

Melvin from Madagascar he's so overrated

and what's the deal between him and that

hippo where giraffes buddy yes something

you would like to say to them Tim you're

a little over and I haven't really been

seeing each other I drop trapped in my

boots every now and again I don't love

the camera t know what it's like to

defecate in front of a hundred thousand

people at any given moment it's

hilarious you know what they say april

showers bring May flowers I'm sorry can

we get some 10 your idiot and you're

making me uncomfortable

well I went into labor this was very

easily haha ladies and gentlemen my baby

meat may know someone handy member scott

cut that up no don't show that to them

hey guys I hope you enjoyed that video

because I literally dress up as a

giraffe in front of my neighbors there

are many people taking photographs and

it was very awkward

you give it a big thumbs up let me know

if you want me to do more of those in

the comments and go follow me on all my

social media will follow me my Instagram

hit me up on their mind Twitter and

subscribe a video every single Monday

and Friday guys even though I've only

been doing videos on mondays but I'll

get access so she's not the summer is

coming up and that being said I think

that that is everything but I really

hope you guys enjoyed that video thanks

so much for watching and I'll ask you

again in the next video bye guys this is

probably harder to film them poorness

For more infomation >> April the Giraffe: I Didn't Know I Was Pregnant - Duration: 3:19.

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Awesome T-Shirt Designs - New Design Shirts #tshirts - Duration: 1:32.

For more infomation >> Awesome T-Shirt Designs - New Design Shirts #tshirts - Duration: 1:32.

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ہائے اوے آج تو مزہ آ گیا ایک دفعہ اس کا سیکسی ڈانس ضرور دیکھیں - Duration: 3:32.

For more infomation >> ہائے اوے آج تو مزہ آ گیا ایک دفعہ اس کا سیکسی ڈانس ضرور دیکھیں - Duration: 3:32.

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Los 4 Tipos De Temperamento 😕 30K Coaching | Elsa Punset | Sandra Burgos - Duration: 5:41.

For more infomation >> Los 4 Tipos De Temperamento 😕 30K Coaching | Elsa Punset | Sandra Burgos - Duration: 5:41.

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The Intelligent Investor by Benjamin Graham | Animated Book Review - Duration: 1:53.

Published in 1949 "The Intelligent Investor" by Benjamin Graham takes on investing approach

called "value investing", a concept he created from his experience. After losing

most of his capital in 1929 market crash, Graham sought safe and proof investing options.

Here are the most important lessons from The Intelligent Investor:

Never give up and learn from your mistakes Although he lost almost all of his capital,

he didn't quit as most would have. Instead, he learned valuable lessons about risk that

resulted in analyzing risks and valuing them. Investing isn't speculating or gambling

Markets should be looked at as an ally. You should only buy when prices are low and sell

when they are high. Minimizing risk

Graham always implied how important it is to buy investments when it's under its true

value. This is allowing profit when the market revalues or offering protection if the market

goes downwards. The margin of safety

The key point here is buying assets when their value is lower than their true value, and

then later on selling those assets when their value is back to normal or even goes up thus

earning a return from your investment. See beyond the horizon

Keep your eyes on the long-term outcome. There is no way of knowing what markets will do,

markets will fluctuate and always come back to its true value.

For more infomation >> The Intelligent Investor by Benjamin Graham | Animated Book Review - Duration: 1:53.

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Hatsune Miku: Project DIVA Future Tone - [PV] "Two-Sided Lovers" (Romaji/English/Español Subs) - Duration: 3:11.

"Two-Sided Lovers" Music & Lyrics by wowaka

I woke up from a dream full of delight

Inside my head-space

A perplexing thing called Love

Took over, and then

I couldn't keep my heart-space

From splitting in two

Never had the capacity to control it

In the first place

With my mostly naive theory of emotion

Somewhere in that spray of words

I was someway, somehow

Looking for a pair of eyes to find out where it's at--LIFE

Every day is full of "why"

Did this, did that, but in the end, it's sayonara baby

One side facing truth, one side running

My two-sided heart

Is there no good out there?

I ask my topsy-turvy self

Inside myself, beside myself

Insides turned inside out, ahhhh

Just touching by instinct

With nothing to say

Hurting, touching, gasping

Feeling like I could climb to heaven

But I'm stuck going nowhere

Here and there

Take that leap to the other side

Get head over heels in love

Breathe from your diaphragm

Jump into a intense taste

Front side, flip side, big as life

Force them together

Stick them over your retinas

Just give yourself to love!

Want-don't-want to see you--NO!

I woke up from a dream full of misery

Inside my head-space

A perplexing thing called Love

Took over, and then

I couldn't keep my heart-space

From splitting in two

No limiter etc. could ever control it

In the first place

Mostly vaguely innocent calamity

Strewn by my swollen ego

Telling me where I'm at

These words I think I've grasped

Every day is full of "why"

Did this, did that, but in the end, it's sayonara baby

One side facing truth, one side running

My two-sided heart

Is there no good out there?

I ask my topsy-turvy self

Inside myself, beside myself

Insides turned inside out, ahhhh

Just touching by instinct

With nothing to say

Hurting, touching, gasping

Feeling like I could climb to heaven

But I'm stuck going nowhere

Here and there

Take that leap to the other side

Hate blindly

Make plans to go today

Make me insist on it

Wait for my life-sized flip side!

Tempt me with a taunt

Sing for the hell of it

Just give yourself to love!

No such thing as love--NO

Get head over heels in love

Take a deep breath

The intensity takes you

Front side, flip side, big as life

Force them together

Stick them over your retinas

Just give yourself to love!

Love love love love--NO!

For more infomation >> Hatsune Miku: Project DIVA Future Tone - [PV] "Two-Sided Lovers" (Romaji/English/Español Subs) - Duration: 3:11.

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Lush How It's Made: Honey Lip Scrub - Duration: 1:26.

(lively music)

- Hi guys, I'm Aura

and today on How It's Made we will make Honey Lip Scrub.

(lively music)

One of the cool things about Honey Lip Scrub

is that it has real Canadian honey

and it will leave your lips soft and plump.

The first step is to get a bunch of jojoba oil,

which will really soften your lips.

Next we'll add our real Canadian honey,

followed by our refreshing peppermint oil.

After we have these ingredients together,

we will quickly mix them up.

Next we add our sugar,

which is a great natural exfoliant.

We give that a quick mix

and then we add our vegan white chocolate.

Once that's mixed

we'll pass it to our production assistants to pack it.

(lively music)

And that's how we make Honey Lip Scrub.

Thanks for watching.

If you're new to our channel,

check out these other videos.

If you have an idea on How It's Made,

comment below.

See you next time.

(lively music)

For more infomation >> Lush How It's Made: Honey Lip Scrub - Duration: 1:26.

-------------------------------------------

Yamaha CS01 and MR10 - Analog single oscillator keyboard and drum machine - Duration: 6:08.

Hello and welcome to another episode of 8-Bit Keys.

So, recently I was visiting my friend Brandon who has very large collection of vintage professional

keyboards and out of the corner of my eye I saw this.

Now, I thought it was a toy keyboard at first because it definitely has that shape and appearance

to it.

But, actually, this is a professional keyboard.

It's a real analog synthesizer.

So here's a closeup of this thing..

This was produced in 1982.

The controls are all ridiculously simple, but I'm not going to have time to demonstrate

every one of them.

I will mention that it has pro style output for headphone and line-output.

However, inserting anything into either of these jacks will disable the internal speaker,

which is weird..

I would have expected that with the headphone jack, but not the line-out.

Now, at first I was baffled by some of the design.

For example, I did notice that it has these little holes here.

Now, I found out that these are actually for straps.

And the reason that the pitch bend and modulation wheel are there is because this is designed

to be strapped on and played on stage like this, and that way you can access the different

wheels.

Also, the line-output ports are on the side.

Which would make sense, because if you were holding it like this, strapped on, then it

would come out, kind of like a guitar.

So, this is definitely meant to be played on stage.

So, let's power it on and see what we can do with it.

Let's play with the different waveforms.

This is triangle, then sawtooth, then square wave, and then pulse wave.

This switch essentially changes octaves, giving the keyboard a wide range of notes to play.

What I find interesting is that if you use the square wave with no modulation and no

envelope, it sounds exactly like a PC speaker from old MS-DOS games.

OK, so let's add some decay to the sound, you can see how that affects it.

OK, let's play with the pulse wave and try modulating it some.

So, I wanted to put together a little multi-track recording for you so you could hear what you

might be able to do with a keyboard like this.

But, there's no real good way to make any drums on this keyboard, so I also my friend

Brandon's Yamaha drum machine.

Now, this is from the same time period and does kind of match the keyboard.

Let me show you a little bit about this thing.

Alright, so this drum machine is about as basic as I have ever seen.

You can change the sounds of some of the instruments, or the volume of certain instruments.

And you can have it play from some pre-set rhythms.

And that's honestly about it.

I think the sounds are also produced with analog circuitry, there are no PCM samples

here.

Alright, so the song you're about to hear was actually not composed by me.

It was actually composed by Anders Jensen, who does a lot of the music for my channel.

But, he actually composed this upon my request as a theme music for the upcoming game that

I'm producing called Planet X2.

So, eventually you're going to hear this same music comming out of a Commodore 64.

But for the moment, you can hear it coming out of this Yamaha.

So let's take this thing apart and see what secrets it hides.

There are just 6 screws on the back.

So this is technically the back side of the board, but one thing that jumps out at me

is how they labelled everything on here.

It's almost like they were inviting modders and hackers to come in here and change things,

which is pretty cool!

So let's take out the board and look at the top.

There's not a lot here other than analog components and this one large IC, but I haven't

been able to find any information on this chip.

Well guys.

As always, we've reached the end.

I hope you found it interesting, and stick around for more content!

For more infomation >> Yamaha CS01 and MR10 - Analog single oscillator keyboard and drum machine - Duration: 6:08.

-------------------------------------------

We Love PBS | The Art Assignment | PBS Digital Studios - Duration: 3:08.

[intro]

You know that little intro you just saw?

Just in case you missed it, we'll play it again.

[play PBSDS intro again]

It tells you that this series is funded by PBS, and without that funding The Art Assignment

would not exist.

With PBS's support and expertise, we've been able to provide free, educational content

over the past 3 years, making over 150 videos, gathering assignments from over 60 artists

in cities all over the country and beyond, who have in turn inspired a community that

has created thousands of artworks in response.

PBS also funds many of your other favorite YouTube channels like Crash Course, BrainCraft,

Idea Channel, and Deep Look.

And their resource for teachers and students in the classroom, PBS LearningMedia, offers

access to free, high-quality educational content to anyone in the U.S.

You may have heard that some dramatic budget cuts have been proposed to a number of US

government agencies and initiatives, including the Corporation for Public Broadcasting.

While these cuts could certainly have an impact on our show, I'm here to talk to you today

about why public television stations and PBS are important to me for other, less selfish,

reasons.

Like a lot of you, I grew up on the enriching, enlightening programming from PBS, starting

with the revelation of watching Crayons get made at the Crayon factory on an episode of

Sesame Street and learning kindness and generosity from the incomparable Mr. Rogers.

Public television also gave me my first exposure to art, when Sister Wendy took me on tours

of museums I couldn't travel to, and Art21 is an amazing series that offers a window

into the lives of working artists, and which helped sparked my own interest in art as a

career.

The Corporation for Public Broadcasting, which provides critical financial support to local

public television and radio stations, currently receives $445 million dollars from the federal

government annually.

That is definitely a lot of money, but to put it in context this costs just a $1.35

per person per year.

That $1.35 per year gives you, and the people you share your world with, an enormous amount

of non-profit educational content.

You can really of public television is America's largest classroom.

68% of all kids ages 2-8 watched their local public television station last year.

If--like me--you don't want this invaluable public service to go away, there are a number

of things you can do:

You can contact your local congressperson and tell them why you love your local station

and PBS.

Or show up at a town hall.

Or make a YouTube video and share it with them.

See the description for a link to help find your representative.

You can also share the message with your friends.

Post on social media about what PBS and your local station mean to you with the hashtag

#ILovePBS

If you want to learn more about why PBS is essential, go to pbs.org/value to find out.

Thank you for your support, and thank you to PBS for making The Art Assignment and so

much educational content possible.

For more infomation >> We Love PBS | The Art Assignment | PBS Digital Studios - Duration: 3:08.

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CS:GO - Useful Anti-Rush Smokes on Cobblestone - Duration: 2:28.

Hey guys, salut mes amis och hallå gubbar.

Maxim here.

Next map in the series, Cbble.

Let's start with the smokes for B. The two ways I have is, in this corner, aim here

for 128 tick and here for matchmaking.

Run just a little bit and jump-throw.

This will land before B entrance.

The terrorist will have no way of passing this smoke before it lands.

Second way, and the safest is in this corner, aim at the top of the hole in the wall, and

throw the smoke when your crosshair meets the bottom.

This smoke needs to be thrown fast.

Next smoke is for drop, go to this wood plank, aim at the right of this wood plank, move

your crosshair up halfway, and throw.

This will create a one-way if you boost yourself up.

It's recommended to first throw an incendiary, then the smoke, then boost.

Next smoke is for middle doors, line yourself up like this, and aim to the left of the black

lines like this.

Not only does it smoke off doors, but it creates a descent one-way, be careful

not to stand too much out in the open or you might get pre-fired.

Last smoke is for A long or catwalk, line yourself up like this and

throw here.

This not only smokes the passage but it creates a convenient one-way as well.

That was the video.

I'll see you guys soon but in the meantime, go bananas!